The site of action of Cystistat® is the urothelium.
Cystistat® has been developed to temporarily replenish the deficient GAG layer on the bladder epithelium. It has a double effect:
Cystistat® has a barrier effect (primary) 15Extracted from Moreland publication which is based on the osteoarthritis model 16
Cystistat® also has a regenerative role (secondary effect) 17In the urothelium, HA is predominantly found at the basal cell membrane 17Cystistat® restores a good environment for cell proliferation 17Cystistat® has a regenerative role of the GAG layer in the bladder and can provide a chance to cure* 1,18* However, late recurrences surpassing the observation period cannot be excluded. 50 % of the patients were free of bladder symptom after primary therapy of Cystistat® without any further therapy during the 5 year follow-up 1