Cystistat® is instilled into the bladder to alleviate symptoms associated with cystitis.

Cystistat® is a sterile sodium hyaluronate solution containing 40 mg/50 mL sodium hyaluronate. This sterile solution is used for instillation into the bladder.

Cystistat® contains a highly purified sodium salt of hyaluronic acid (HA) produced by fermentation. HA plays a vital role in extracellular matrix homeostasis, wound healing, and tissue regeneration.10

Cystistat® has a wide range of published papers supporting the treatment of cystitis.

• Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC) 1
• Recurrent Bacterial Cystitis (RBC) by the protection of the urothelium 11, 12
• Radiation-induced cystitis (RIC) 5, 13, 14

Cystistat® has been developed to temporarily replenish the deficient GAG layer on the bladder epithelium. It has a double effect:

• Cystistat® has a barrier effect (primary) 15Extracted from Moreland publication which is based on the osteoarthritis model 16
• Cystistat® also has a regenerative role (secondary effect) 17In the urothelium, HA is predominantly found at the basal cell membrane 17Cystistat® restores a good environment for cell proliferation 17Cystistat® has a regenerative role of the GAG layer in the bladder and can provide a chance to cure* 1,18* However, late recurrences surpassing the observation period cannot be excluded. 50 % of the patients were free of bladder symptom after primary therapy of Cystistat® without any further therapy during the 5 year follow-up 1